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名字：TPOP146
描述：Description: TPOP146 is a potent and selective CBP/P300 Benzoxazepine Bromodomain Inhibitor. TPOP146 showed 134 nM affinity for CBP with excellent selectivity over other bromodomains. Deregulation of CBP/P300 has been reported in cancer and chromosomal rearrangement of the CBP/P300 locus results in oncogenic fusions with either MOZ acetyltransferase or the mixed linage leukemia (MLL) gene product and CBP/MLL fusions have been detected in acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) after treatment with topoisomerase inhibitors.
规格:
理论分析：THEORETICAL ANALYSIS
MedKoo Cat#: 406826
Name: TPOP146
CAS#: 2018300-62-2
Chemical Formula: C27H35N3O5
Exact Mass: 481.2577
Molecular Weight: 481.593
Elemental Analysis: C, 67.34; H, 7.33; N, 8.73; O, 16.61
技术数据：Appearance: Solid powder Purity: >98% (or refer to the Certificate of Analysis) Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Solubility: Soluble in DMSO Shelf Life: >2 years if stored properly Drug Formulation: This drug may be formulated in DMSO Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months). Harmonized System Code: 293490
描述：Description: TPOP146 is a potent and selective CBP/P300 Benzoxazepine Bromodomain Inhibitor. TPOP146 showed 134 nM affinity for CBP with excellent selectivity over other bromodomains. Deregulation of CBP/P300 has been reported in cancer and chromosomal rearrangement of the CBP/P300 locus results in oncogenic fusions with either MOZ acetyltransferase or the mixed linage leukemia (MLL) gene product and CBP/MLL fusions have been detected in acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) after treatment with topoisomerase inhibitors.
规格:
理论分析：THEORETICAL ANALYSIS
MedKoo Cat#: 406826
Name: TPOP146
CAS#: 2018300-62-2
Chemical Formula: C27H35N3O5
Exact Mass: 481.2577
Molecular Weight: 481.593
Elemental Analysis: C, 67.34; H, 7.33; N, 8.73; O, 16.61
技术数据：Appearance: Solid powder Purity: >98% (or refer to the Certificate of Analysis) Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Solubility: Soluble in DMSO Shelf Life: >2 years if stored properly Drug Formulation: This drug may be formulated in DMSO Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months). Harmonized System Code: 293490
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